Review
Nature Reviews Immunology 8, 935-947 (December 2008) | doi:10.1038/nri2455
Article series: Tissue-specific immune responses
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
Miriam Merad1, Florent Ginhoux1 & Matthew Collin1,2 About the authors
Abstract
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity.
- View At a Glance
Author affiliations
- Department of Gene and Cell Medicine and Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA.
- Haematological Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Correspondence to: Miriam Merad1 Email: Miriam.Merad@mssm.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Langerhans cells: daughters of monocytesNature Immunology News and Views (01 Mar 2006)
Langerhans cells: immigrants or residents?Nature Immunology News and Views (01 Dec 2002)
See all 7 matches for News And ViewsRESEARCH
Dermal-resident CD14 + cells differentiate into Langerhans cellsNature Immunology Article (01 Dec 2001)
Keratinocytes Function as Accessory Cells for Presentation of Endogenous Antigen Expressed in the EpidermisJournal of Investigative Dermatology Original Article
See all 55 matches for Research
