Table of contents
November 2008 Vol 8 No 11
From the editors
p823 | doi:10.1038/nri2446
Research Highlights
Mucosal immunology: Mismanaged ER stress and inflammation | PDF (133 KB)
p824 | doi:10.1038/nri2435
Autoimmunity: Balancing B-cell subsets in EAE | PDF (140 KB)
p825 | doi:10.1038/nri2439
T cells: Survival tricks | PDF (136 KB)
p825 | doi:10.1038/nri2442
Lymphocyte responses: Germinal-centre B cells take control | PDF (142 KB)
p826 | doi:10.1038/nri2441
HIV: Learning from a monkey! | PDF (152 KB)
p826 | doi:10.1038/nri2443
In brief
Dendritic cells | Lymphocyte migration | Tumour immunology | PDF (124 KB)
p826 | doi:10.1038/nri2445
Autoimmunity: Gut bacteria keep you healthy | PDF (129 KB)
p827 | doi:10.1038/nri2440
Tumour immunology: Regulating MDSC recruitment | PDF (158 KB)
p828 | doi:10.1038/nri2437
In the news
Nobel prize to virus detectives | PDF (101 KB)
p828 | doi:10.1038/nri2444
Editor's note: Tumour-induced immune modulation of sentinel lymph nodes | PDF (95 KB)
p901 | doi:10.1038/nri2447
Progress
Cytokine-mediated regulation of antimicrobial proteins
Jay K. Kolls, Paul B. McCray, Jr & Yvonne R. Chan
p829 | doi:10.1038/nri2433
Antimicrobial proteins are an ancient mechanism of defence against pathogens at skin and mucosal surfaces. As discussed in this Progress article, new studies identify dynamic cross-regulation between cytokines and antimicrobial peptides, which contributes to immunity and homeostasis at these sites.
Reviews
New regulators of NF-
B in inflammation
Sankar Ghosh & Matthew S. Hayden
p837 | doi:10.1038/nri2423
Activation of nuclear factor-
B (NF-B) is crucial for initiating inflammatory responses. In this Review, Sankar Ghosh and Matthew Hayden discuss the roles of several newly identified regulators of the NF-B pathway, as well as some old factors that have been assigned new functions.
TRIM family proteins and their emerging roles in innate immunity
Keiko Ozato, Dong-Mi Shin, Tsung-Hsien Chang & Herbert C. Morse, III
p849 | doi:10.1038/nri2413
The tripartite motif-containing (TRIM) proteins are best known for their roles in the restriction of infection by lentiviruses. Here, the authors describe the recent studies that reveal broader antiviral and antimicrobial activities of TRIM proteins, including an involvement in the pathogen-recognition and signalling pathways.
Cross-regulation between herpesviruses and the TNF superfamily members
John R. 
edý,
Patricia G. Spear
&
Carl F. Ware
p861 | doi:10.1038/nri2434
Herpesviruses have evolved numerous strategies to outsmart the host and establish persistent infection. Important targets of viral entry and immunomodulation are the tumour-necrosis factor superfamily proteins. This Review describes the central role of these proteins in both virus survival and host defence.
Mammalian glycosylation in immunity
Jamey D. Marth & Prabhjit K. Grewal
p874 | doi:10.1038/nri2417
This Review discusses how the diversity of glycan structures that are produced in the secretory pathway and are displayed at the cell surface and in extracellular compartments can have both homeostatic and pathogenic effects on the development and function of the mammalian immune system.
Perspectives
Opinion
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases
David S. Schneider & Janelle S. Ayres
p889 | doi:10.1038/nri2432
These authors express their opinion that we should devote more research attention to uncovering the mechanisms by which a host can tolerate, as well as resist, infection with a pathogen. New drugs to increase tolerance to infection should provide therapies to which pathogens will not develop resistance.
Opinion
Do T cells need endogenous peptides for activation?
Nicholas R. J. Gascoigne
p895 | doi:10.1038/nri2431
This article proposes that endogenous peptides can enhance the recognition of antigenic peptides by T cells and, based on results from MHC class I- and class II-restricted T-cell systems, that CD4 and CD8 have different roles in the recognition of endogenous peptide–MHC complexes.
