Review
Nature Reviews Immunology 8, 874-887 (November 2008) | doi:10.1038/nri2417
Corrected online: 15 October 2008
Mammalian glycosylation in immunity
Jamey D. Marth1 & Prabhjit K. Grewal1 About the authors
Abstract
Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple biological functions that encompass ligands for proteinaceous receptors known as lectins. Since the discovery that selectins and their glycan ligands are important for the regulation of leukocyte trafficking, it has been shown that additional features of the vertebrate immune system are also controlled by endogenous cellular glycosylation. This Review focuses on the emerging immunological roles of the mammalian glycome.
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Author affiliations
- Department of Cellular and Molecular Medicine and the Howard Hughes Medical Institute, 9500 Gilman Drive-0625, University of California San Diego, La Jolla, California 92093, USA.
Correspondence to: Jamey D. Marth1 Email: jmarth@ucsd.edu
* In the version of this article initially published online, there was an unnecessary "of" in the abstract. This error has been corrected for the print, HTML and PDF versions of the article.
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