Table of contents
From the editors
p745 | doi:10.1038/nri2429
Research Highlights
Innate immunity: Swarms defend against parasites | PDF (165 KB)
p746 | doi:10.1038/nri2420
T cells: Selection and tolerance involve autophagy | PDF (129 KB)
p747 | doi:10.1038/nri2418
In brief
Inflammation | Vaccines | HIV | PDF (124 KB)
p747 | doi:10.1038/nri2428
Autoimmunity: The threat within | PDF (163 KB)
p748 | doi:10.1038/nri2419
Inflammation: Dealing with excessive cell death | PDF (146 KB)
p748 | doi:10.1038/nri2425
In brief
Inflammation | Viral immunity | Natural killer T cells | PDF (129 KB)
p749 | doi:10.1038/nri2430
T-cell activation: Variation is the spice of life | PDF (143 KB)
p750 | doi:10.1038/nri2421
Innate immunity: STING: adding to the antiviral arsenal | PDF (135 KB)
p750 | doi:10.1038/nri2424
Innate immunity: PIMS knows friends and foes | PDF (141 KB)
p751 | doi:10.1038/nri2422
Regulatory T cells: MicroRNAs maintain identity | PDF (150 KB)
p752 | doi:10.1038/nri2426
Web Watch
A systems approach to immunology | PDF (112 KB)
p752 | doi:10.1038/nri2427
Reviews
The alliance of sphingosine-1-phosphate and its receptors in immunity
Juan Rivera, Richard L. Proia & Ana Olivera
p753 | doi:10.1038/nri2400
Recent research has shown that the interaction of sphingosine-1-phosphate with its receptors (S1PR1–S1PR5) has an essential role in regulating immune responses, not only through the control of immune-cell trafficking but also through effects on immune-cell function. Understanding these effects holds promise for the use of S1PR ligands as immunomodulatory therapeutics.
Article series: Tissue-specific immune responses
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence
Tobias Junt, Elke Scandella & Burkhard Ludewig
p764 | doi:10.1038/nri2414
The anatomy of secondary lymphoid organs defines the ability of an organism to respond to pathogens. In this Review, the authors describe how the functional microarchitecture of these structures is both a determinant and a result of antimicrobial immunity.
Harmful molecular mechanisms in sepsis
Daniel Rittirsch, Michael A. Flierl & Peter A. Ward
p776 | doi:10.1038/nri2402
Sepsis is an overwhelming systemic inflammatory response to severe microbial infection or extensive tissue damage. In this Review, the authors highlight recent molecular data that help to unravel the mechanisms that underlie dysregulation of immune responses in this syndrome.
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
Alfred Singer, Stanley Adoro & Jung-Hyun Park
p788 | doi:10.1038/nri2416
What determines whether a developing thymocyte becomes a CD4+ or CD8+ T cell has been an issue of longstanding debate. Here, the authors review the models that have been proposed to explain CD4/CD8-lineage choice and update us on the environmental and transcription factors that might mediate this decision.
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
Christian Weber, Alma Zernecke & Peter Libby
p802 | doi:10.1038/nri2415
Atherosclerosis is now widely considered to be a chronic inflammatory disease that is driven by the activities of many leukocyte subpopulations. Here, the authors describe the contribution of different immune-cell subsets to each stage of the disease, revealing complex and dynamic interactions.
Perspective
Opinion
A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways
Lionel B. Ivashkiv
p816 | doi:10.1038/nri2396
The activation of immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors influences signalling pathways downstream of other receptor types. In this Opinion, Lionel Ivashkiv describes how ITAM-dependent signalling can differentially influence cellular responses to Toll-like-receptor ligands and cytokines.
