Review
Nature Reviews Immunology 8, 764-775 (October 2008) | doi:10.1038/nri2414
Article series: Tissue-specific immune responses
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence
Tobias Junt1, Elke Scandella2 & Burkhard Ludewig2 About the authors
Abstract
Secondary lymphoid organs (SLOs) are tissues that facilitate the induction of adaptive immune responses. These organs capture pathogens to limit their spread throughout the body, bring antigen-presenting cells into productive contact with their cognate lymphocytes and provide niches for the differentiation of immune effector cells. Therefore, the microanatomy of SLOs defines the ability of an organism to respond to pathogens. SLO microarchitecture is, at the same time, extremely adaptable to environmental changes. In this Review, we discuss recent insights into the function and plasticity of the SLO microenvironment with regards to antimicrobial immune defence.
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Author affiliations
- Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
- Research Department, Kantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Correspondence to: Tobias Junt1 Email: tobias.junt@novartis.com
Correspondence to: Burkhard Ludewig2 Email: burkhard.ludewig@kssg.ch
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