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Volume 8 Issue 10, October 2008

From The Editors

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Research Highlight

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In Brief

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Research Highlight

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In Brief

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Research Highlight

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Web Watch

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Review Article

  • Recent research has shown that the interaction of sphingosine-1-phosphate with its receptors (S1PR1–S1PR5) has an essential role in regulating immune responses, not only through the control of immune-cell trafficking but also through effects on immune-cell function. Understanding these effects holds promise for the use of S1PR ligands as immunomodulatory therapeutics.

    • Juan Rivera
    • Richard L. Proia
    • Ana Olivera
    Review Article
  • Sepsis is an overwhelming systemic inflammatory response to severe microbial infection or extensive tissue damage. In this Review, the authors highlight recent molecular data that help to unravel the mechanisms that underlie dysregulation of immune responses in this syndrome.

    • Daniel Rittirsch
    • Michael A. Flierl
    • Peter A. Ward
    Review Article
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Opinion

  • The activation of immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors influences signalling pathways downstream of other receptor types. In this Opinion, Lionel Ivashkiv describes how ITAM-dependent signalling can differentially influence cellular responses to Toll-like-receptor ligands and cytokines.

    • Lionel B. Ivashkiv
    Opinion
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