Table of contents
January 2008 Vol 8 No 1
From the editors
p1 | doi:10.1038/nri2248
Research Highlights
Cell migration: Immunosurveillance by recirculating HSPCs | PDF (226 KB)
p2 | doi:10.1038/nri2242
Lymphocyte development: SLAM dunk for innate T cells | PDF (200 KB)
p3 | doi:10.1038/nri2243
In the news
Aggravating asthma | PDF (76 KB)
p3 | doi:10.1038/nri2247
Inflammation: TIM3: dual role in immunity | PDF (226 KB)
p4 | doi:10.1038/nri2239
Transplantation: Making space for HSCs | PDF (198 KB)
p4 | doi:10.1038/nri2241
HIV: The escape artist | PDF (275 KB)
p4 | doi:10.1038/nri2246
In brief
Immune tolerance | Infectious disease | T-cell development | PDF (93 KB)
p5 | doi:10.1038/nri2250
Antibody responses: IgA — peacemaker in the gut | PDF (894 KB)
p6 | doi:10.1038/nri2237
Signalling: The ins and outs of Ca2+ signalling in mast cells | PDF (402 KB)
p6 | doi:10.1038/nri2245
Tumour Immunology: Stalemate | PDF (146 KB)
p7 | doi:10.1038/nri2238
Lung inflammation: Disarming neutrophils in cystic fibrosis | PDF (204 KB)
p8 | doi:10.1038/nri2244
In brief
Inflammation | Mucosal immunology | Autoimmunity | PDF (96 KB)
p8 | doi:10.1038/nri2249
Reviews
Launching the T-cell-lineage developmental programme
Ellen V. Rothenberg, Jonathan E. Moore & Mary A. Yui
p9 | doi:10.1038/nri2232
In this article, Ellen Rothenberg and colleagues review the key transcription factors and other regulatory factors involved in the processes of specification and commitment to the T-cell lineage, and outline the outstanding questions in the field.
Germinal centres: role in B-cell physiology and malignancy
Ulf Klein & Riccardo Dalla-Favera
p22 | doi:10.1038/nri2217
Germinal centres are the main source of memory B cells and plasma cells that produce high-affinity antibodies in the body. In this Review, Ulf Klein and Riccardo Dalla-Favera describe the relationship between the cellular and molecular dynamics of germinal centres and the pathogenesis of B-cell lymphomas.
Fc
receptors as regulators of immune responses
Falk Nimmerjahn & Jeffrey V. Ravetch
p34 | doi:10.1038/nri2206
The function of the various subclasses of IgG molecules is mediated by the family of Fc receptors for IgG (Fc
Rs). This Review outlines how FcRs regulate immune responses and the relevance of this information to developing new therapies for treating human diseases.
Complement driven by conformational changes
Piet Gros, Fin J. Milder & Bert J. C. Janssen
p48 | doi:10.1038/nri2231
The recent resolution of the long-awaited structures of the central components of the complement system — C3 and factor B — has finally revealed the molecular details of complement activation. With this, clues to how complement activation is regulated and evaded by pathogens are also emerging.
Immunological aspects of cancer chemotherapy
Laurence Zitvogel, Lionel Apetoh, François Ghiringhelli & Guido Kroemer
p59 | doi:10.1038/nri2216
Here, the authors describe how the antitumour effects of many conventional cancer treatments involve the immune system, by promoting immunogenic tumour-cell death or by direct stimulation of immune cells. Taking advantage of this 'bystander effect' may help in the fight against cancer.
Perspectives
Opinion
Creating immune privilege: active local suppression that benefits friends, but protects foes
Andrew L. Mellor & David H. Munn
p74 | doi:10.1038/nri2233
How do antigenic tumour cells and chronic pathogens exploit natural regulatory mechanisms to become non-immunogenic? Andrew Mellor and David Munn propose that such immune unresponsiveness is an indirect consequence of the need to control the potentially lethal consequences of unrestrained immunity to innocuous substances.
Opinion
How microorganisms tip the balance between interleukin-12 family members
Stanislas Goriely, Markus F. Neurath & Michel Goldman
p81 | doi:10.1038/nri2225
Distinct members of the interleukin-12 (IL-12) cytokine family can differentially regulate T-cell-mediated inflammation. In this Opinion article, the authors propose that microbial products and endogenous mediators can control the balance between these cytokines, thereby directly regulating the inflammatory response.
Correspondence
Correspondence: Efficacy of regulatory T-cell immunotherapy: are inflammatory cytokines key determinants?
Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Suryasarathi Dasgupta, Michel D. Kazatchkine & Srini V. Kaveri
doi:10.1038/nri2138-c1
Correspondence: In vivo neutralization of inflammatory cytokines might not be necessary for regulatory T-cell immunotherapy
Manuela Battaglia & Maria-Grazia Roncarolo
doi:10.1038/nri2138-c2
