Abstract

Interleukin-12p70 (IL-12p70) induces T-helper-1-cell responses and IL-23, a related cytokine, is the master switch in several T-cell-mediated inflammatory disorders. IL-27, another member of the IL-12 family, regulates innate and adaptive immune responses. Recently, distinct combinations of transcription factors have been shown to regulate the expression of the genes that encode these three cytokines. Toll-like receptor ligands, in association with other microbial products and endogenous mediators, tip the balance between the expression of IL-12 family members and thereby may control the outcome of T-cell-mediated inflammation. On this basis, we present a novel perspective on the pathogenesis and regulation of inflammatory disorders.

Author affiliations

1. Stanislas Goriely and Michel Goldman are at the Institute for Medical Immunology, Université Libre de Bruxelles, 8 rue Adrienne Bolland, B-6041 Charleroi, Belgium.
2. Markus F. Neurath is at the Laboratory of Immunology, First Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
3. These authors contributed equally to this work.

Correspondence to: Michel Goldman^1,3 Email: mgoldman@ulb.ac.be

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