Review
Nature Reviews Immunology 7, 665-677 (September 2007) | doi:10.1038/nri2153
Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
Stephen D. Miller1, Danielle M. Turley1 & Joseph R. Podojil1 About the authors
Abstract
The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.
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Author affiliations
- Department of Microbiology–Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Correspondence to: Stephen D. Miller1 Email: s-d-miller@northwestern.edu
Published online 10 August 2007
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