Perspectives
Nature Reviews Immunology 7, 645-650 (August 2007) | doi:10.1038/nri2136
There is a Correspondence and an Author's reply (November Issue) associated with this article.
Focus on: Immune tolerance
Timeline: A decade of AIRE
Diane Mathis1 About the author & Christophe Benoist1
Abstract
In 1997, the autoimmune regulator (AIRE) gene was identified as the locus underlying susceptibility to the polyendocrine autoimmune disease known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). In the intervening 10 years, it has become increasingly clear that this rare disorder has provided us with an illuminative window on one of the most fundamental processes of the immune system — the establishment and maintenance of self tolerance.
Author affiliations
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Diane Mathis and Christophe Benoist are at The Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
Email: cbdm@joslin.harvard.edu
Published online 20 July 2007
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