Progress
Nature Reviews Immunology 7, 425-428 (June 2007) | doi:10.1038/nri2097
Focus on: Cytokines & cytokine therapies
TH1 cells control themselves by producing interleukin-10
Anne O'Garra1 & Paulo Vieira2 About the authors
Abstract
Inflammatory T helper 1 (TH1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from TH2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that TH1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.
Author affiliations
- Anne O'Garra is at the Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
- Paulo Vieira is at the Unité Développement des Lymphocytes, Institut Pasteur, 75724 Paris Cedex 15, France.
Correspondence to: Anne O'Garra1 Email: aogarra@nimr.mrc.ac.uk
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