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TH1 cells control themselves by producing interleukin-10

Nature Reviews Immunology volume 7, pages 425–428 (2007)Cite this article

Abstract

Inflammatory T helper 1 (TH1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from TH2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that TH1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.

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Figure 1: The production of IL-10 during immune responses.

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Acknowledgements

We acknowledge M. Saraiva for comments on the manuscript. A.O.G. is funded by the Medical Research Council, UK.

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Authors and Affiliations

  1. Anne O'Garra is at the Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.,

    Anne O'Garra

  2. Paulo Vieira is at the Unité Développement des Lymphocytes, Institut Pasteur, 75724 Paris Cedex 15, France.,

    Paulo Vieira

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Correspondence to Anne O'Garra.

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O'Garra, A., Vieira, P. TH1 cells control themselves by producing interleukin-10. Nat Rev Immunol 7, 425–428 (2007). https://doi.org/10.1038/nri2097

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