Table of contents
May 2007 Vol 7 No 5
From the editors
p319 | doi:10.1038/nri2088
Research Highlights
Innate immunity: Triggering RIG-I
p321 | doi:10.1038/nri2081
Autoimmunity: Regulatory T cells in autoimmunity
p322 | doi:10.1038/nri2078
B cells: TSLP and B-cell homeostasis
p322 | doi:10.1038/nri2080
Lymphocyte migration: Exiting lymphoid organs
p323 | doi:10.1038/nri2074
Tumour immunology: Beneficial loss
p324 | doi:10.1038/nri2083
T cells: Tuning a T cell's excitation threshold
p324 | doi:10.1038/nri2086
T cells: LIGHTing up lipid metabolism
p324 | doi:10.1038/nri2087
Natural killer T cells: iGb3: to be or not to be?
p325 | doi:10.1038/nri2082
In the news
Stem-cell therapy for type 1 diabetes
p326 | doi:10.1038/nri2084
Cellular cytotoxicity: Jinxed mice
p326 | doi:10.1038/nri2085
Reviews
Prospects for the use of NK cells in immunotherapy of human cancer
Hans-Gustaf Ljunggren & Karl-Johan Malmberg
p329 | doi:10.1038/nri2073
Natural killer cells were so named because of their ability to lyse tumour cells. Although initial studies have provided encouraging results, several challenges remain in optimizing the use of NK cells in therapeutic settings, as is described in this Review.
Graft-versus-host disease
Warren D. Shlomchik
p340 | doi:10.1038/nri2000
Graft-versus-host disease (GVHD) is an important clinical problem in haematopoietic stem-cell transplantation. Here, Warren Shlomchik describes advances in our understanding of this complex disease and the cells that are involved in its initiation and development, based on studies from experimental models.
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Luke A. J. O'Neill & Andrew G. Bowie
p353 | doi:10.1038/nri2079
In this Review, Luke O'Neill and Andrew Bowie discuss the role of the five adaptor proteins that are involved in Toll-like receptor (TLR) signalling, and provide a detailed molecular description of the earliest phase of TLR signal transduction.
New developments in Fc
RI regulation, function and inhibition
Stefan Kraft & Jean-Pierre Kinet
p365 | doi:10.1038/nri2072
Signalling through the high-affinity Fc receptor for IgE (Fc
RI) mediates many of the features of allergic diseases. This Review provides an update of the FcRI signalling pathways, induced with and without antigen, and how their regulation by inhibitory receptors may have therapeutic potential.
Innate immunity of the newborn: basic mechanisms and clinical correlates
Ofer Levy
p379 | doi:10.1038/nri2075
The neonatal immune system faces a number of unique immunological challenges as the newborn moves from the sterile intra–uterine environment to a world rich in foreign antigens. How does the innate immune system deal with these challenges and what are the clinical correlations?
Immune evasion by Kaposi's sarcoma-associated herpesvirus
Laurent Coscoy
p391 | doi:10.1038/nri2076
Kaposi's sarcoma-associated herpesvirus (KSHV), the aetiological agent of Kaposi's sarcoma, establishes a persistent infection in its host. To do this the virus must evade detection by the immune system. But what mechanisms does the virus employ to do this?
Perspective
Opinion
Rethinking peptide supply to MHC class I molecules
Laurence C. Eisenlohr, Lan Huang & Tania N. Golovina
p403 | doi:10.1038/nri2077
The DRiP hypothesis proposes that most peptides that bind to MHC class I molecules are derived from newly synthesized defective proteins. Here, the authors revise this hypothesis and propose that some peptides result from the random delivery of unchaperoned nascent polypeptides to the proteasome.
