FIGURE 4 | Mechanisms of injury by tissue-infiltrating alloreactive T cells.
From the following article:
Warren D. Shlomchik
Nature Reviews Immunology 7, 340-352 (May 2007)
doi:10.1038/nri2000
Activated alloreactive CD8+ T cells require direct cognate interactions with MHC-class-I-expressing parenchymal targets (non-haematopoietic tissues such as skin, liver or intestine) to induce injury through the expression of CD95 ligand (CD95L) and the production of cytolytic granules. By contrast, infiltrating CD4+ T cells can mediate graft-versus-host disease (GVHD) without directly contacting MHC-class-II-expressing non-haematopoietic tissues. CD4+ T cells could be activated locally by tissue macrophages and dendritic cells (DCs) to release inflammatory mediators, such as tumour-necrosis factor (TNF), interleukin-1 (IL-1) and interferon (IFN), or alternatively may activate recipient antigen-bearing macrophages which induce tissue injury. APC, antigen-presenting cell. TCR, T-cell receptor.
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