Review

Nature Reviews Immunology 7, 329-339 (May 2007) | doi:10.1038/nri2073

Prospects for the use of NK cells in immunotherapy of human cancer

Hans-Gustaf Ljunggren1 & Karl-Johan Malmberg1  About the authors

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Current insights into the molecular specificities that regulate natural killer (NK)-cell function suggest that it might be possible to design NK-cell-based immunotherapeutic strategies against human cancer. Here, we describe evidence for NK-cell targeting of human tumours and address crucial questions that, in our opinion, require consideration for the development of successful NK-cell-based therapies. Appropriately used, we predict that NK cells will have a role, both directly and in combination with other treatment modalities, in future treatment of cancer.

Author affiliations

  1. Centre for Infectious Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.
    Email: hans-gustaf.ljunggren@ki.se;
    Email: kalle.malmberg@ki.se

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