Table of contents
April 2007 Vol 7 No 4
From the editors
p245 | doi:10.1038/nri2067
Research Highlights
Lymphocyte activation: Unequal inheritance initiates T-cell diversity
p247 | doi:10.1038/nri2064
HIV: Double trouble
p248 | doi:10.1038/nri2055
In the news
Blast from the past
p248 | doi:10.1038/nri2071
Mucosal immunology: IECs keep the peace
p249 | doi:10.1038/nri2060
Antigen presentation: Dampening down destruction in dendritic cells
p250 | doi:10.1038/nri2066
Natural killer cells: Tumour cells tout trogocytosis
p250 | doi:10.1038/nri2068
Immunogenetics: Lucky for some
p251 | doi:10.1038/nri2059
B cells: Making space for newcomers
p252 | doi:10.1038/nri2063
Insect immunity: Immune adaptation in flies
p252 | doi:10.1038/nri2065
Regulatory T cells: WASP helps TReg cells sting their prey
p253 | doi:10.1038/nri2058
Reviews
Siglecs and their roles in the immune system
Paul R. Crocker, James C. Paulson & Ajit Varki
p255 | doi:10.1038/nri2056
Through binding ubiquitous sialic-acid residues on cell surfaces, the Siglec family of lectins promote cell–cell interactions and regulate the functions of numerous immune-cell types. This Review describes the emerging roles of Siglecs in pathogen recognition and endocytosis.
Scientific barriers to developing vaccines against avian influenza viruses
Kanta Subbarao & Tomy Joseph
p267 | doi:10.1038/nri2054
The pandemic threat posed by avian influenza viruses highlights the need for new safe and efficient vaccines. However, several unique obstacles are faced by researchers in the development of these vaccines against avian influenza viruses. What are these obstacles and how can we overcome them?
Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
Kirsty C. Newman & Eleanor M. Riley
p279 | doi:10.1038/nri2057
Natural killer (NK)-cell activation by most pathogens seems to occur indirectly, and is dependent on signals from accessory cells, such as monocytes, macrophages and dendritic cells. This Review examines how the interactions between NK cells, accessory cells and a diverse range of pathogens occur.
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Hiroshi Takayanagi
p292 | doi:10.1038/nri2062
Osteoimmunology encompasses the many interactions that are now known to occur between the immune and skeletal systems. This Review examines the delicate network of interactions between immune and bone cells, how their molecular mechanisms compare and contrast, and the crosstalk between the two systems.
Perspectives
Opinion
FOXP3 modifies the phenotypic and functional properties of regulatory T cells
Daniel J. Campbell & Steven F. Ziegler
p305 | doi:10.1038/nri2061
The transcription factor forkhead box P3 (FOXP3) is essential for the development and function of regulatory T cells. Here, the authors propose that FOXP3 might also influence how a cell responds to T-cell receptor stimulation and what tissue-homing receptors it expresses.
Opinion
Modulation of the immunological synapse: a key to HIV-1 pathogenesis?
Oliver T. Fackler, Andres Alcover & Olivier Schwartz
p310 | doi:10.1038/nri2041
The success and pathogenicity of HIV-1 largely resides in the function of the viral protein Nef. Here, the authors propose that Nef modulates a T cell's ability to form an immunological synapse and modulates T-cell activation to favour viral replication and spread.
Correspondence
Correspondence: Is dental caries reaching epidemic proportions in Brazil?
Ramiro Mendonca Murata & Vanessa Pardi
doi:10.1038/nri1857-c1
