Review
Nature Reviews Immunology 7, 118-130 (February 2007) | doi:10.1038/nri2017
Humanized mice in translational biomedical research
Leonard D. Shultz1, Fumihiko Ishikawa2 and Dale L. Greiner3 About the authors
Abstract
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
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Author affiliations
- The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
- RIKEN, Research Center for Allergy and Immunology, Yokahama Institute, 1-7-22 Suehiro-cho, Tsurumi-Ku, Yokohama, Kanagawa, 230-0045, Japan.
- University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 218, Worcester, Massachusetts 01605, USA.
Correspondence to: Leonard D. Shultz1 Email: lds@jax.org
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