Table of contents
November 2007 Vol 7 No 11
From the editors
p831 | doi:10.1038/nri2213
Research Highlights
Innate immunity: TLR3: rising above redundancy | PDF (355 KB)
p833 | doi:10.1038/nri2208
Innate immunity: T cells calm the storm | PDF (459 KB)
p834 | doi:10.1038/nri2197
B-Cell Development: (micro)Control of B-cell development | PDF (305 KB)
p834 | doi:10.1038/nri2209
In brief
Natural killer cells | T-cell responses | PDF (117 KB)
p834 | doi:10.1038/nri2210
Dendritic cells: XBP1 — aiding survival | PDF (165 KB)
p836 | doi:10.1038/nri2201
Regulatory T cells: Not so self-centred after all | PDF (326 KB)
p836 | doi:10.1038/nri2202
In the news
HIV vaccine trial halted | PDF (92 KB)
p836 | doi:10.1038/nri2211
Inflammation: Cryopyrin — another guise of death | PDF (167 KB)
p837 | doi:10.1038/nri2203
In brief
Inflammation | Mucosal immunology | Immune regulation | PDF (113 KB)
p837 | doi:10.1038/nri2212
Lymphocyte development: Turning B cells into T cells | PDF (310 KB)
p838 | doi:10.1038/nri2196
Dendritic cells: Plasmacytoid dendritic cells in psoriasis | PDF (539 KB)
p838 | doi:10.1038/nri2198
Immune regulation: A fourth dimension to the stromal scaffold | PDF (217 KB)
p839 | doi:10.1038/nri2207
Reviews
Common themes in the assembly and architecture of activating immune receptors
Matthew E. Call & Kai W. Wucherpfennig
p841 | doi:10.1038/nri2186
Many receptors of the immune system are composed of ligand-binding subunits combined with signalling subunits. Here, Matthew Call and Kai Wucherpfennig review recent studies on the assembly and architecture of these receptors and discuss the implications of these studies.
Immunological and genetic bases of new primary immunodeficiencies
László Maródi & Luigi D. Notarangelo
p851 | doi:10.1038/nri2195
The study of individuals with primary immunodeficiencies (PIDs) has helped to define mechanisms that control the development and function of the immune system. This Review focuses on recently characterized PIDs and describes the genetic defects that are associated with these disorders.
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
Dominique Ferrandon, Jean-Luc Imler, Charles Hetru & Jules A. Hoffmann
p862 | doi:10.1038/nri2194
Ferrandon and colleagues describe the recognition of bacterial and fungal pathogens by Drosophila melanogaster, the signalling pathways that are activated and the antimicrobial peptides that are induced, highlighting parallels with the mammalian immune system.
Regulatory T cells and infection: a dangerous necessity
Yasmine Belkaid
p875 | doi:10.1038/nri2189
To survive a given infection, a host needs to mount a controlled immune response. Regulatory T cells are important components of the regulatory network, which benefit the host by limiting immunopathology but may also be detrimental to the host by favouring pathogen survival.
Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins
Antonella Viola & Neetu Gupta
p889 | doi:10.1038/nri2193
The existence of membrane rafts has been widely debated, but as discussed in this Review, recent evidence suggests that, by tethering and trapping membrane microdomains, the actin cytoskeleton has an important role in orchestrating membrane-raft dynamics during lymphocyte signalling.
Perspectives
Innovation
Laser scanning cytometry: understanding the immune system in situ
Margaret M. Harnett
p897 | doi:10.1038/nri2188
In this article, Margaret Harnett describes the technology of laser scanning cytometry and outlines the benefits of this technique in allowing the detection of signalling and functional events that occur during cell–cell interactions in situ.
Timeline
The origin and application of experimental autoimmune encephalomyelitis
Alan G. Baxter
p904 | doi:10.1038/nri2190
Here, Alan Baxter provides an historical view of experimental autoimmune encephalomyelitis (EAE). Its value in providing insight into T–cell immunology is clear, but might the reductionist approach to EAE have hindered our appreciation of the polyantigenic responses that occur in multiple sclerosis and thereby its clinical relevance?
Correspondence
Correspondence: Does the deficiency of Aire in mice really resemble human APECED?
Eliisa Kekäläinen, Aaro Miettinen & T. Petteri Arstila
doi:10.1038/nri2136-c1