Review
Nature Reviews Immunology 7, 889-896 (November 2007) | doi:10.1038/nri2193
There is an Erratum (December Issue) associated with this article.
Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins
Antonella Viola1 & Neetu Gupta2 About the authors
Abstract
The existence of plasma-membrane-raft microdomains has been widely debated during the past few years. However, it is clear that during lymphocyte stimulation a lipid-based reorganization occurs at the plasma membrane, with markers of the membrane rafts being selectively recruited to key active regions of the cell. Recent reports have demonstrated that membrane-raft dynamics are controlled by proteins that are linked to the actin cytoskeleton and have suggested a new model for the plasma membrane based on protein–lipid interactions. This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation.
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Author affiliations
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Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Milan, Italy. University of Milan, Faculty of Medicine, Italy.
Email: antonella.viola@humanitas.it -
Department of Immunology, Cleveland Clinic, 9500 Euclid Avenue, NE40, Cleveland, Ohio 44195, USA.
Email: guptan@ccf.org
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