Table of contents
October 2007 Vol 7 No 10
From the editors
p745 | doi:10.1038/nri2181
Research Highlights
T Cells: Co-receptor tuning | PDF (289 KB)
p747 | doi:10.1038/nri2179
T-Cell responses: Frequency variation is the spice of life | PDF (150 KB)
p748 | doi:10.1038/nri2178
T-Cell development: Thymocyte-selected CD4+ T cells | PDF (115 KB)
p748 | doi:10.1038/nri2180
In brief
| PDF (111 KB)
p748 | doi:10.1038/nri2183
Antibodies: A new way of sticking the ends together | PDF (234 KB)
p749 | doi:10.1038/nri2185
Mucosal immunology: Maintaining balance in the gut | PDF (143 KB)
p750 | doi:10.1038/nri2176
Innate immunity: An unexpected role for NF-
B | PDF
(256 KB)
p750 | doi:10.1038/nri2182
Autoimmunity: Controlling promiscuity | PDF (160 KB)
p751 | doi:10.1038/nri2175
Reviews
Genetic analysis of resistance to viral infection
Bruce Beutler, Celine Eidenschenk, Karine Crozat, Jean-Luc Imler, Osamu Takeuchi, Jules A. Hoffmann & Shizuo Akira
p753 | doi:10.1038/nri2174
Recent advances using genetic analysis in both insects and mammals have expanded our understanding of how the immune system senses viruses and initiates immune responses against them. But what are the biochemical pathways involved and how do immune cells work together to control viral infection?
Unveiling the roles of autophagy in innate and adaptive immunity
Beth Levine & Vojo Deretic
p767 | doi:10.1038/nri2161
Autophagy — a cellular process for recycling, remodelling or disposing of unwanted cytoplasmic constituents — is emerging as an important pathway in innate and adaptive immunity. This Review describes its role in pathogen defence, antigen processing and presentation, T-cell homeostasis and disease.
Calcium signalling and cell-fate choice in B cells
Andrew M. Scharenberg, Lisa A. Humphries & David J. Rawlings
p778 | doi:10.1038/nri2172
Fluctuations in cytosolic calcium concentrations affect numerous signals involved in the development and function of B cells. Recent advances have expanded our understanding of the mechanisms involved in the regulation of cytosolic calcium concentrations and how this influences B-cell fate.
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting
Paul J. Tacken, I. Jolanda M. de Vries, Ruurd Torensma & Carl G. Figdor
p790 | doi:10.1038/nri2173
The ability of dendritic cells to drive immune responses has led researchers to target these cells in vaccination therapy. Here, the authors review the development of the field, from ex vivo loading studies to in vivo targeting using specific receptors.
Evolving functions of endothelial cells in inflammation
Jordan S. Pober & William C. Sessa
p803 | doi:10.1038/nri2171
Endothelial cells, which line the blood and lymph vessels, control the movement of proteins from the blood into the tissue. However, as discussed here, these often overlooked cells are also active participants in and regulators of the inflammatory process.
Perspectives
Opinion
IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-
B activation
Paolo Puccetti & Ursula Grohmann
p817 | doi:10.1038/nri2163
Here, the authors propose a new mechanism of immune tolerance. It involves the production of the immunoregulatory enzyme IDO (indoleamine 2,3-dioxygenase) induced by reverse signalling and non-canonical nuclear factor-
B activation in dendritic cells interacting with regulatory-T-cell-expressed co-receptors.
Viewpoint
Reflections on the clonal-selection theory
Melvin Cohn, N. Av Mitchison, William E. Paul, Arthur M. Silverstein, David W. Talmage & Martin Weigert
p823 | doi:10.1038/nri2177
Fifty years after F. Macfarlane Burnet published his seminal paper on the clonal-selection theory of antibody diversity, six key scientists provide their thoughts and opinions on how this theory was received and how it has helped to shape immunology as we know it today.
