Table of contents
July 2006 Vol 6 No 7
From the editors
p491 | doi:10.1038/nri1893
Research Highlights
Innate immunity: Sensing viruses
p492 | doi:10.1038/nri1887
Autoimmunity: Cytokine partnership to destruction
p493 | doi:10.1038/nri1889
In brief
Immunotherapy | Immune regulation | Immune regulation
p493 | doi:10.1038/nri1895
B cells: Ships in the night
p494 | doi:10.1038/nri1888
Tumour immunology: Partners in crime
p494 | doi:10.1038/nri1891
Autoimmunity: Multipronged effects of FOXP3 mutations
p495 | doi:10.1038/nri1894
Natural killer T cells: In the absence of AIRE...
p496 | doi:10.1038/nri1890
Autoimmunity: Quietening TIM in MS
p496 | doi:10.1038/nri1892
Reviews
Dynamic imaging of the immune system: progress, pitfalls and promise
Ronald N. Germain, Mark J. Miller, Michael L. Dustin & Michel C. Nussenzweig
p497 | doi:10.1038/nri1884
This article aims to make the methodology behind the recent spate of papers reporting in situ immune-cell imaging more accessible to the reader and to highlight potential artefacts so that the reader can analyse the data more critically.
The immune response in atherosclerosis: a double-edged sword
Göran K. Hansson & Peter Libby
p508 | doi:10.1038/nri1882
Recent advances in our understanding of the mechanisms of atherosclerosis, which is an inflammatory disease that involves the formation of plaques in the arteries, indicate that the immune response can both promote and reduce disease.
Self-tolerance of natural killer cells
David H. Raulet & Russell E. Vance
p520 | doi:10.1038/nri1863
The way in which natural killer (NK) cells acquire tolerance to self is still not fully understood. Possible mechanisms involved in NK-cell self-tolerance are discussed in detail in this Review, with an emphasis on the involvement of MHC-class-I-specific receptors.
The many paths to p38 mitogen-activated protein kinase activation in the immune system
Jonathan D. Ashwell
p532 | doi:10.1038/nri1865
The p38 proteins are mitogen-activated protein kinases (MAPKs) that are activated by the MAPK cascade in response to pro-inflammatory cytokines and cell stresses. However, an alternative pathway of p38 activation might be particularly important in T cells and inflammatory cells.
Neutrophil serine proteases: specific regulators of inflammation
Christine T. N. Pham
p541 | doi:10.1038/nri1841
This article describes recent studies defining the in vivo importance of neutrophil serine proteases in the intracellular and extracellular killing of microorganisms, as well as in the regulation of non-infectious inflammatory processes, such as the modulation of active cytokine concentrations.
Perspectives
Opinion
The thymus and T-cell commitment: the right niche for Notch?
Eric J. Jenkinson, William E. Jenkinson, Simona W. Rossi & Graham Anderson
p551 | doi:10.1038/nri1883
The precise point at which haematopoietic precursors commit to being T cells is a hotly debated area. Eric Jenkinson and colleagues propose that, in the fetus, commitment occurs prethymically and Notch signalling in the thymus reaffirms rather than determines such commitment.
Science and society
The scientific and public-health imperative for a vaccine against dental caries
Martin A. Taubman & David A. Nash
p555 | doi:10.1038/nri1857
Dental caries is caused by a bacterial infection that is prevalent worldwide. This article discusses the scientific evidence that vaccination could prevent the spread of this disease, and it puts forward the argument, in terms of public health, for the development of such a vaccine.
Correspondence
Correspondence: Immunomodulatory role of statins in autoimmune disease: is there a role for human 
T cells?
Francesco Dieli & Nadia Caccamo
| doi:10.1038/nri1839-c1
