Review
Nature Reviews Immunology 6, 433-446 (June 2006) | doi:10.1038/nri1864
CEACAM1: contact-dependent control of immunity
Scott D. Gray-Owen1 & Richard S. Blumberg2 About the authors
Abstract
The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. Recent studies show that there is an important role for members of the CEACAM family in modulating the immune responses associated with infection, inflammation and cancer. In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types.
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Author affiliations
- Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
- Gastroenterology Division, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence to: Scott D. Gray-Owen1 Email: scott.gray.owen@utoronto.ca
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