Table of contents
June 2006 Vol 6 No 6
From the editors
p425 | doi:10.1038/nri1872
Research Highlights
Macrophages: Regulatory circuit in the lungs
p426 | doi:10.1038/nri1876
T-cell activation: CCL3 and CCL4 actively recruit CD8+ T cells
p427 | doi:10.1038/nri1862
In the news
Rocky road for gene therapy
p427 | doi:10.1038/nri1880
B cells: Spread yourself thin
p428 | doi:10.1038/nri1871
Autoimmunity: Reversing diabetes
p428 | doi:10.1038/nri1877
Innate immunity: Finding flagellin
p429 | doi:10.1038/nri1870
Natural killer cells: Adaptive killers
p430 | doi:10.1038/nri1868
Immunotherapy: Co-operation for tumour targeting
p430 | doi:10.1038/nri1873
In brief
Immunotherapy | Phagocytosis | Mucosal immunology
p430 | doi:10.1038/nri1875
Cytokines: IL-25 expels worms
p431 | doi:10.1038/nri1874
Innate immunity: A new way to get complement
p432 | doi:10.1038/nri1861
In brief
Regulatory T cells | Antigen-presenting cells | Macrophages
p432 | doi:10.1038/nri1878
Reviews
CEACAM1: contact-dependent control of immunity
Scott D. Gray-Owen and Richard S. Blumberg
p433 | doi:10.1038/nri1864
Members of the carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family are involved in intercellular binding interactions affecting various normal and pathogenic processes. This article provides an overview of the role of CEACAMs in immunity, focusing on the function of CEACAM1.
Defensins in innate antiviral immunity
Mary E. Klotman and Theresa L. Chang
p447 | doi:10.1038/nri1860
Defensins are important effectors of innate immunity. Recent studies have elucidated the mechanisms of their antiviral activity, indicating that they have both direct effects on viruses and indirect effects on target cells. In addition, defensins have immunomodulatory activities.
The SIRP family of receptors and immune regulation
A. Neil Barclay and Marion H. Brown
p457 | doi:10.1038/nri1859
Signal-regulatory proteins (SIRPs) are members of the paired-receptor family, which regulate and fine-tune immune responses. Their role in vivo is influenced by the different affinities of the SIRPs for their ligands and by their expression levels.
Confounding B-cell defences: lessons from a staphylococcal superantigen
Gregg J. Silverman and Carl S. Goodyear
p465 | doi:10.1038/nri1853
Studies of microbial superantigens that target B cells provide better understanding of B-cell-receptor interactions and supraclonal dysregulation. Their ability to induce tolerance that subverts host defences may provide new therapeutic approaches for the treatment of B-cell-mediated autoimmune and neoplastic diseases.
Perspectives
Essay
Dendritic cells in a mature age
Caetano Reis e Sousa
p476 | doi:10.1038/nri1845
In this article, the ways in which dendritic-cell nomenclature has evolved are discussed, focusing on the new trend to specifically define a dendritic cell not only by its phenotypic maturation state but also by its function.
Innovation
In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease
Robert S. Negrin and Christopher H. Contag
p484 | doi:10.1038/nri1879
Bioluminescence imaging is emerging as a useful tool for visualizing immune reactions. Importantly, this technique allows researchers to pinpoint the location of cells at numerous time points in intact animals. This is proving particularly useful in the study of graft-versus-host disease.
Erratum: Immunology and immunotherapy of Alzheimer's disease
Howard L. Weiner and Dan Frenkel
p490 | doi:10.1038/nri1881