Table of contents
April 2006 Vol 6 No 4
From the editors
p253 | doi:10.1038/nri1844
Research Highlights
Antigen presentation: DCs spot the difference
p254 | doi:10.1038/nri1824
In brief
Asthma and allergy | Lymphoid organs | Technique
p255 | doi:10.1038/nri1829
Viral immunity: Turning off class switching
p255 | doi:10.1038/nri1834
Transplantation: Soluble CD154 initiates rejection
p256 | doi:10.1038/nri1825
Vaccines: Learning from our successes
p256 | doi:10.1038/nri1827
T-cell memory: Location, location, location
p257 | doi:10.1038/nri1833
In the news
T-cell vaccine for MS
p258 | doi:10.1038/nri1830
T-cell memory: Less is more
p258 | doi:10.1038/nri1831
Regulatory T cells: Getting down to the specifics
p258 | doi:10.1038/nri1832
In brief
Insect immunity | Regulatory T cells | Immunotherapy
p259 | doi:10.1038/nri1836
T cells: De novo generation of IL-17-producing T cells
p260 | doi:10.1038/nri1826
T-cell development: Life and death with the IAN family
p260 | doi:10.1038/nri1828
Reviews
DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis
Yang Xu
p261 | doi:10.1038/nri1804
This article provides an overview of the mechanisms by which eukaryotic cells sense and respond to chromosomal double-stranded DNA breaks and describes the importance of this response for the development of lymphocytes and the development of effective innate and adaptive immune responses.
MHC class II proteins and disease: a structural perspective
E. Yvonne Jones, Lars Fugger, Jack L. Strominger and Christian Siebold
p271 | doi:10.1038/nri1805
MHC class II molecules are important factors that contribute to the susceptibility of an individual to autoimmune disease. Jones and colleagues look for clues to their involvement in disease by analysing crystal structures of peptide–MHC-class II complexes.
ITAM-mediated tonic signalling through pre-BCR and BCR complexes
John G. Monroe
p283 | doi:10.1038/nri1808
This Review describes how tonic signalling — ligand-independent signalling from Ig
–Ig
-containing receptors, such as the pre-B-cell receptor (pre-BCR) and BCR — differs from ligand-dependent signalling and then outlines recent advances in our understanding of how tonic signalling is initiated and regulated.
Regulatory T cells, tumour immunity and immunotherapy
Weiping Zou
p295 | doi:10.1038/nri1806
Regulatory T cells have a role in suppressing immune responses against tumours. Here, Weiping Zou reviews the nature of these cells, how they affect current therapeutic protocols and the ways in which their effects can be modified to improve antitumour immunity.
Caspases at the crossroads of immune-cell life and death
Richard M. Siegel
p308 | doi:10.1038/nri1809
The caspase family has traditionally been divided into two groups: those involved in regulating apoptosis and those involved in regulating inflammation. However, as discussed in this Review, recent data indicate that capases can also regulate immune-cell development, activation and differentiation.
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Esther M. Sternberg
p318 | doi:10.1038/nri1810
Evidence for crosstalk between the central nervous system and innate immune cells is accumulating. As discussed by Esther Sternberg, neural factors that first amplify and then temper pro-inflammatory responses have a crucial role in pathogen defence and in preventing toxic shock.
Perspective
Opinion
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
Chen Dong
p329 | doi:10.1038/nri1807
Chen Dong proposes that the recently identified subset of CD4+ T cells that produce interleukin-17 represent a distinct lineage of inflammatory T helper (TH) cells that develop independently of the cytokines and transcription factors that regulate TH1- and TH2-cell differentiation.
Correspondence
Correspondence: Glucocorticoid treatment of patients with SARS: implications for mechanisms of immunopathology
Nirmal S. Panesar
p334 | doi:10.1038/nri1835-c1
Author Reply: Glucocorticoid contribution to lymphopaenia and immunpathology in patients with SARS
Stanley Perlman and Ajai A. Dandekar
p334 | doi:10.1038/nri1835-c2
