Table of contents
February 2006 Vol 6 No 2
From the editors
p85 | doi:10.1038/nri1802
Research Highlights
Transplantation: Normal conditions suit HSCs
p86 | doi:10.1038/nri1797
T-cell development: Why 3D is better than 2D
p87 | doi:10.1038/nri1791
Lymphocyte signalling: Linking the scaffold to the workforce
p87 | doi:10.1038/nri1799
Inflammation: Switching on the inflammasome
p88 | doi:10.1038/nri1789
In the news
Rotavirus vaccines
p88 | doi:10.1038/nri1795
Inflammation: T-bet links innate and adaptive immune responses
p88 | doi:10.1038/nri1801
In brief
T-cell development | Haematopoiesis | Haematopoiesis
p89 | doi:10.1038/nri1793
Haematopoiesis: HSCs find their niche
p90 | doi:10.1038/nri1796
T-cell signalling: FYN keeps ITCH under control
p90 | doi:10.1038/nri1798
Cytokines: TWEAK and TNF: Yin and Yang in innate immunity
p91 | doi:10.1038/nri1790
In brief
Apoptosis | T-cell signalling | Autoimmunity
p92 | doi:10.1038/nri1794
Immune responses: A single ER protein for multiple processes
p92 | doi:10.1038/nri1800
Focus on: Early lymphocyte development
Reviews
Bone-marrow haematopoietic-stem-cell niches
Anne Wilson and Andreas Trumpp
p93 | doi:10.1038/nri1779
All cells of the immune system are derived from precursor cells in the bone marrow known as haematopoietic stem cells (HSCs). This Review describes recent advances in our understanding of the specialized bone-marrow niches that regulate HSC differentiation and self-renewal.
Microenvironmental niches in the bone marrow required for B-cell development
Takashi Nagasawa
p107 | doi:10.1038/nri1780
Recent studies have identified potential factors and cellular environments that foster B-cell development in the bone marrow. As discussed, knowledge of such microenvironmental niches and of B-cell precursor populations has advanced our understanding of the spatiotemporal regulation of B-cell development.
From stem cell to T cell: one route or many?
Avinash Bhandoola and Arivazhagan Sambandam
p117 | doi:10.1038/nri1778
Although T cells are derived from haematopoietic stem cells in the bone marrow, T-cell development occurs in the thymus. This Review describes recent data indicating that several cell populations in the bone marrow are able to populate the thymus and generate T cells.
Journey through the thymus: stromal guides for T-cell development and selection
Yousuke Takahama
p127 | doi:10.1038/nri1781
As thymocytes travel through the thymus, they not only receive signals from stromal cells but also deliver signals to stromal cells to generate the appropriate stromal environment. Takahama describes the factors involved in this lympho–stromal crosstalk for thymocyte trafficking and T-cell-repertoire selection.
Reviews
Pathogen–endoplasmic-reticulum interactions: in through the out door
Craig R. Roy, Suzana P. Salcedo and Jean-Pierre E. Gorvel
p136 | doi:10.1038/nri1775
Different pathogens have evolved distinct strategies to promote their survival in host cells. This Review describes the contribution of the endoplasmic reticulum to host defence and the mechanisms by which pathogens interacting with the endoplasmic reticulum subvert the host immune response.
Mucosal vaccines: the promise and the challenge
Marian R. Neutra and Pamela A. Kozlowski
p148 | doi:10.1038/nri1777
Mucosal immunization could be our best hope for protection against pathogens that infect mucosal tissues. Here, the authors describe how our accumulating knowledge of the mechanisms of mucosal immune defence is being applied to mucosal vaccine design, in particular against HIV.
Perspective
Opinion
Chemokines: more than just road signs
Martin F. Bachmann, Manfred Kopf and Benjamin J. Marsland
p159 | doi:10.1038/nri1776
Recent data indicate that chemokines have a role in regulating dendritic-cell maturation. In this Opinion article it is proposed that this ensures that dendritic cells migrating to the lymph node arrive in a fully mature state that is optimal for T-cell priming.
