Review
Nature Reviews Immunology 6, 919-929 (December 2006) | doi:10.1038/nri1980
SNAREing immunity: the role of SNAREs in the immune system
Jennifer L. Stow1, Anthony P. Manderson1 & Rachael Z. Murray1 About the authors
Abstract
The trafficking of molecules and membranes within cells is a prerequisite for all aspects of cellular immune functions, including the delivery and recycling of cell-surface proteins, secretion of immune mediators, ingestion of pathogens and activation of lymphocytes. SNARE (soluble-N-ethylmaleimide-sensitive-factor accessory-protein receptor)-family members mediate membrane fusion during all steps of trafficking, and function in almost all aspects of innate and adaptive immune responses. Here, we provide an overview of the roles of SNAREs in immune cells, offering insight into one level at which precision and tight regulation are instilled on immune responses.
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Author affiliations
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Correspondence to: Jennifer L. Stow1 Email: j.stow@imb.uq.edu.au
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