Abstract

The recognition of antigen by B- or T-cell receptors initiates an intracellular signalling cascade that results in the nuclear translocation and activation of the transcription factor nuclear factor-B (NF-B). NF-B is an important regulator of lymphocyte development and function, and its dysregulation is associated with many immune disorders. Defining the mechanisms that transmit signals from the antigen receptor to NF-B is therefore an important goal for immunologists. In this Review, we merge information gleaned from research of the innate immune system with what we know about antigen-receptor signals in the adaptive immune system, to propose a cohesive model of how antigen receptors activate NF-B.

Author affiliations

1. Department of Immunology, Childrens Hospital & Regional Medical Centre, 307 Westlake Avenue North, Suite 300, Seattle, Washington 98109, USA.

Correspondence to: David J. Rawlings¹ Email: drawling@u.washington.edu

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