Table of contents
January 2006 Vol 6 No 1
From the editors
p1 | doi:10.1038/nri1762
Research Highlights
T-cell signalling: SLAP and CBL cooperate to bring down TCR
p2 | doi:10.1038/nri1772
Inflammation: An eggcellent way to avoid attraction
p3 | doi:10.1038/nri1763
B-cell responses: TLRs are crucial for B cells too
p3 | doi:10.1038/nri1773
Evolution: Evidence stacks up for evolutionary link
p4 | doi:10.1038/nri1764
Antibodies: IgG effector function: a question of balance
p4 | doi:10.1038/nri1766
In the news
Cold—cancer link
p4 | doi:10.1038/nri1769
In brief
Dendritic cells | Phagocytosis | Autoimmunity
p5 | doi:10.1038/nri1768
Autoimmunity: Keeping CD4+ T cells under control
p6 | doi:10.1038/nri1770
Immune responses: Inhibition zipped
p6 | doi:10.1038/nri1774
Antigen presentation: Trimming peptides for presentation
p7 | doi:10.1038/nri1765
In brief
Development | Immune evasion | B-cell responses
p8 | doi:10.1038/nri1767
Tumour immunology: TGF
suppresses cytotoxicity
p8 | doi:10.1038/nri1771
Reviews
Signalling pathways and molecular interactions of NOD1 and NOD2
Warren Strober, Peter J. Murray, Atsushi Kitani & Tomohiro Watanabe
p9 | doi:10.1038/nri1747
NOD1 and NOD2 are intracellular sensors of microbial components derived from bacterial peptidoglycan. This Review describes the signalling pathways of these NOD proteins and details their role in the maintenance of mucosal homeostasis and the induction of mucosal immunity.
Pre-erythrocytic malaria vaccines: towards greater efficacy
Adrian V. S. Hill
p21 | doi:10.1038/nri1746
Adrian Hill gives us a rundown of the latest developments in malaria vaccine research, and he highlights the recent promising results from clinical trials in Africa of vaccines that target the pre-erythrocytic stages of the malaria life cycle.
Dectin-1: a signalling non-TLR pattern-recognition receptor
Gordon D. Brown
p33 | doi:10.1038/nri1745
Although Toll-like receptors (TLRs) are the most widely studied pattern-recognition receptors (PRRs), non-TLR PRRs are also important sensors of pathogens. This Review describes the role of one non-TLR PRR, dectin-1, in immunity and the implications of this role for the function of other non-TLR PRRs.
Combinatorial roles of nuclear receptors in inflammation and immunity
Christopher K. Glass & Sumito Ogawa
p44 | doi:10.1038/nri1748
This Review focuses on the regulation of inflammation by peroxisome-proliferator-activated receptors (PPARs) and liver X receptors (LXRs). These nuclear receptors work in combination with the glucocorticoid receptor (another member of the nuclear-receptor superfamily) to coordinate the inflammatory response.
Immune regulation by SLAM family receptors and SAP-related adaptors
André Veillette
p56 | doi:10.1038/nri1761
Members of the signalling lymphocytic activation molecule (SLAM) family of receptors associate with adaptor molecules of the SLAM-associated protein (SAP) family and have an important role in various aspects of innate and adaptive immune responses.
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
Gary A. Koretzky, Farhad Abtahian & Michael A. Silverman
p67 | doi:10.1038/nri1750
This article describes the recent studies that elucidate the mechanism of action of the adaptor proteins SLP76 and SLP65. It details their crucial role in signalling by immunoreceptors and integrins, as well as their further unexpected roles in vascular development and leukaemia.
Perspective
Opinion
Co-evolution of a primordial peptide-presentation system and cellular immunity
Thomas Boehm
p79 | doi:10.1038/nri1749
In this Opinion article, Thomas Boehm proposes that quality-control mechanisms, such as the MHC peptide-presentation system, that tame immunoreceptor self-reactivity might be derived from an ancestral mechanism that guided sexual selection and similarly used information contained in intracellular peptide sequences.
