Review
Nature Reviews Immunology 5, 521-531 (July 2005) | doi:10.1038/nri1648
Focus on: IMMUNE-CELL COMMUNICATION
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
Christopher A. Hunter1 About the author
Abstract
Understanding the factors that influence T helper 1 (TH1)- and TH2-cell responses has been one of the main focuses of immunology for almost 20 years. Whereas the central role of interleukin-12 (IL-12) in the generation of TH1 cells has long been appreciated, subsequent studies indicated that IL-23 and IL-27, two cytokines that are closely related to IL-12, also regulate TH1-cell responses. However, as discussed in this article, it is now recognized that the ability of IL-23 to stimulate a unique T-cell subset to produce IL-17 has a dominant role in autoimmune inflammation. By contrast, IL-27 has a role in limiting the intensity and duration of adaptive immune responses.
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Author affiliations
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Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
Email: chunter@phl.vet.upenn.edu
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