Review
Nature Reviews Immunology 5, 318-330 (April 2005) | doi:10.1038/nri1593
Heat-shock proteins induce T-cell regulation of chronic inflammation
Willem van Eden1, Ruurd van der Zee1 & Berent Prakken1 About the authors
Abstract
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.
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Author affiliations
- Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands.
Correspondence to: Willem van Eden1 Email: w.eden@vet.uu.nl
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