Abstract

The TEC-family protein tyrosine kinases ITK, RLK and TEC have been identified as key components of T-cell-receptor signalling that contribute to the regulation of phospholipase C-, the mobilization of Ca²⁺ and the activation of mitogen-activated protein kinases. Recent data also show that TEC kinases contribute to T-cell-receptor-driven actin reorganization and cell polarization, which are required for productive T-cell activation. Functional studies have implicated TEC kinases as important mediators of pathways that control the differentiation of CD4⁺ T helper cells. Here, we review studies of signalling pathways that involve TEC kinases and how these pathways might contribute to the regulation of T-helper-cell differentiation and function.

Author affiliations

1. National Human Genome Research Institute, National Institutes of Health, 4A38/49 Convent Drive, Bethesda, Maryland 20892, USA.

Correspondence to: Pamela L. Schwartzberg¹ Email: pams@mail.nih.gov

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