Review
Nature Reviews Immunology 5, 136-148 (February 2005) | doi:10.1038/nri1548
The tetraspanin web modulates immune-signalling complexes
Shoshana Levy1 & Tsipi Shoham1 About the authors
Abstract
The tetraspanin web represents a new concept of molecular interactions in the immune system. Whereas most surface immune-modulating molecules involve receptor–ligand interactions, tetraspanins associate with partner proteins and facilitate their lateral positioning in the membrane. Moreover, the same tetraspanin molecule can associate with different proteins depending on the cell type. Most importantly, members of this family tend to associate with each other, together with their partners, in membrane microdomains that provide a scaffold for the transmission of external stimuli to intracellular-signalling components.
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Author affiliations
- Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, California 94305, USA.
Correspondence to: Shoshana Levy1 Email: levy@cmgm.stanford.edu
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RESEARCH
CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifsThe EMBO Journal Article (15 Jan 2001)
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