Review
Nature Reviews Immunology 5, 835-843 (November 2005) | doi:10.1038/nri1711
Corrected online: 23 October 2005
There is an Erratum (1 December 2005) associated with this article.
NK cells in HIV infection: Paradigm for protection or targets for ambush
Anthony S. Fauci1, Domenico Mavilio1 & Shyam Kottilil1 About the authors
Abstract
Natural killer cells are a crucial component of the innate immune response to certain tumours and to various viruses, fungi, parasites and bacteria. HIV has infected more than 60 million people worldwide and has led to more than 23 million deaths. At present, there are 
40 million people who are living with HIV infection, and there were 5 million new infections in 2004. As part of the innate immune system, natural killer cells might have an important role in host defence against HIV infection, as well as in the control of HIV replication in vivo. In this regard, it is important to understand how natural killer cells and HIV interact. This Review focuses on the role of natural killer cells in controlling HIV infection and on the impact of HIV and HIV-viraemia-induced immune activation on natural-killer-cell function.
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Author affiliations
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 31, Room 7A04, 31 Center Drive, MSC 2520, Bethesda, Maryland 20892-2520, USA.
Correspondence to: Anthony S. Fauci1 Email: afauci@niaid.nih.gov
Published online 20 October 2005
* When originally published, the thirteenth row in Table 1 contained incorrect information.
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