Cell-surface enzymes in control of leukocyte trafficking

doi:doi:10.1038/nri1705

From the following article:

Marko Salmi & Sirpa Jalkanen

Nature Reviews Immunology 5, 760-771 (October 2005)

doi:10.1038/nri1705

Supplementary Information S1

S1 | Leukocyte-extravasation cascade in vivo. Leukocyte-endothelial-cell contacts were visualized in a living, anaesthetized mouse, using intravital microscopy. In an inflamed venule of cremaster muscle, numerous rolling cells can be seen (moving from top to bottom). There are also many firmly adherent leukocytes (some indicated by red arrows) and cells that have transmigrated (some indicated by blue arrows). Non-interacting cells (for example, erythrocytes) move too fast to be distinguished as individual cells.The blood flow is from the top to the bottom. The video runs at real-time speed, and the yellow bar indicates a distance of 30 micro m.