Review
Nature Reviews Immunology 4, 553-564 (July 2004) | doi:10.1038/nri1394
Neonatal adaptive immunity comes of age
Becky Adkins1, Claude Leclerc2 & Stuart Marshall-Clarke3 About the authors
Abstract
The past decade has brought great strides in our understanding of adaptive immunity in neonatal mice. Although poor immune responses are commonly observed, it is now clear that mature function can be achieved by all arms of the adaptive immune system. An ever-increasing body of evidence indicates that the neonatal period of life is a unique developmental stage in which responses are highly plastic and dependent on the conditions of antigen exposure. This review focuses on our new understanding in mice and, where it is clear that related phenomena occur, in humans.
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Author affiliations
- Department of Microbiology and Immunology, University of Miami Medical School, Miami, Florida 33136, USA.
- Unit of Biology of Immune Regulation, Institut Pasteur, Paris 75015, France.
- Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3GE, UK.
Correspondence to: Becky Adkins1 Email: radkins@med.miami.edu
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