Review
Nature Reviews Immunology 4, 110-122 (February 2004) | doi:10.1038/nri1268
Role of the cytoskeleton during leukocyte responses
Miguel Vicente-Manzanares1 & Francisco Sánchez-Madrid1 About the author
Abstract
The cytoskeleton is a cellular network of structural, adaptor and signalling molecules that regulates most cellular functions that are related to the immune response, including migration, extravasation, antigen recognition, activation and phagocytosis by different subsets of leukocytes. Recently, a large number of regulatory elements and structural constituents of the leukocyte cytoskeleton have been identified. In this review, we discuss the composition and regulation of the different cytoskeletal elements and their role in immune responses.
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Author affiliations
- Servicio de Immunología, Hospital Universitario de la Princesa, c/Diego de León 62, 28006-Madrid, Spain.
Correspondence to: Francisco Sánchez-Madrid1 Email: fsanchez.hlpr@salud.madrid.org
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