Review
Nature Reviews Immunology 4, 889-899 (November 2004) | doi:10.1038/nri1488
Forkhead-box transcription factors and their role in the immune system
Paul J. Coffer1 & Boudewijn M. T. Burgering1 About the authors
Abstract
It is more than a decade since the discovery of the first forkhead-box (FOX) transcription factor in the fruit fly Drosophila melanogaster. In the intervening time, there has been an explosion in the identification and characterization of members of this family of proteins. Importantly, in the past few years, it has become clear that members of the FOX family have crucial roles in various aspects of immune regulation, from lymphocyte survival to thymic development. This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.
- View At a Glance
Author affiliations
- Department of Pulmonary Diseases, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
- Department of Physiological Chemistry, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Correspondence to: Paul J. Coffer1 Email: p.coffer@azu.nl
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Foxp3 and Aire in thymus-generated T reg cells: a link in self-toleranceNature Immunology News and Views (01 Apr 2007)
Twenty-first century Foxp3Nature Immunology News and Views (01 Apr 2003)
See all 6 matches for News And ViewsRESEARCH
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3BOncogene Original Article
Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in MiceJournal of Cerebral Blood Flow & Metabolism Original Article
See all 24 matches for Research
