Review
Nature Reviews Immunology 4, 775-786 (October 2004) | doi:10.1038/nri1462
The multifaceted roles of TRAFs in the regulation of B-cell function
Gail A. Bishop1 About the author
Abstract
Tumour-necrosis factor receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor proteins that are important in lymphocyte activation and apoptosis. Many studies of TRAFs have used models of exogenous overexpression by non-lymphoid cells. However, the actions of TRAFs present at normal levels in lymphoid cells often differ considerably from those that have been established in non-lymphocyte overexpression models. As I discuss here, information obtained from studying these molecules in physiological settings in B cells reveals that they have several roles, which are both unique and overlapping. These include activation of kinases and transcription factors, and interactions with other signalling proteins, culminating in the induction or inhibition of biological functions.
- View At a Glance
Author affiliations
-
Departments of Microbiology and Internal Medicine, The University of Iowa, Veterans' Affairs Medical Center, Iowa City, Iowa 52242, USA.
Email: gail-bishop@uiowa.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Toward small-molecule agonists of TNF receptorsNature Chemical Biology News and Views (01 Dec 2005)
RESEARCH
CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complexThe EMBO Journal Article (01 Jun 2001)
See all 42 matches for Research
