Review
Nature Reviews Immunology 3, 454-462 (June 2003) | doi:10.1038/nri1111
The TIM gene family: emerging roles in immunity and disease
Vijay K. Kuchroo1, Dale T. Umetsu2, Rosemarie H. DeKruyff2 & Gordon J. Freeman3 About the authors
Abstract
The search for cell-surface markers that can distinguish T helper 1 (TH1) cells from TH2 cells has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin (TIM) proteins, some of which are differentially expressed by TH1 and TH2 cells. The role of the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases.
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Author affiliations
- Center for Neurologic Diseases, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
- Division of Immunology and Allergy, Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
Correspondence to: Vijay K. Kuchroo1 Email: vkuchroo@rics.bwh.harvard.edu
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