Review

Nature Reviews Immunology 3, 304-316 (April 2003) | doi:10.1038/nri1055

Immune functions encoded by the natural killer gene complex

Wayne M. Yokoyama1 & Beatrice F. M. Plougastel1  About the authors

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There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

Author affiliations

  1. Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Barnes-Jewish Hospital and Washington University School of Medicine, Box 8045, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

Correspondence to: Wayne M. Yokoyama1 Email: yokoyama@imgate.wustl.edu

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