Review
Nature Reviews Immunology 3, 269-279 (April 2003) | doi:10.1038/nri1052
Cytokine control of memory T-cell development and survival
Kimberly S. Schluns1 & Leo Lefrançois1 About the authors
Abstract
Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor 
-chain (c)-cytokine family — in particular, interleukin-7 (IL-7) and IL-15 — act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained.
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Author affiliations
- Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1319, USA.
Correspondence to: Leo Lefrançois1 Email: llefranc@neuron.uchc.edu
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