ANTERIOR-CHAMBER-ASSOCIATED IMMUNE DEVIATION (ACAID). Systemic antigen-specific tolerance that develops after inoculation of antigen into the immune-privileged site of the anterior chamber of the eye.
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE). Inflammation of the brain and spinal cord that is generally induced by the administration of myelin basic protein or myelin oligodendrocyte glycoprotein and adjuvants to disease-susceptible strains of mice.
INTROGRESSION By a process of genetic
backcrossing, DNA from a chromosomal segment of one mouse strain is inserted into the homologous region of another mouse strain.
MYELOID DENDRITIC CELLS Dendritic cells that develop from myeloid, as opposed to lymphoid, precursors and that express cell-surface markers that are characteristic of the myeloid lineage.
NON-OBESE DIABETIC MICE (NOD mice). These mice spontaneously develop a form of autoimmune diabetes that shares many genetic, immunological and pathological features with the human disease insulin-dependent diabetes mellitus. These mice are the most widely studied animal model of experimental autoimmune disease.
T HELPER 1/2 (TH1/TH2). At least two distinct subsets of activated CD4+ T cells have been described. TH1 cells produce IFN-
, lymphotoxin and TNF, and support cell-mediated immunity. TH2 cells produce IL-4, IL-5 and IL-13, support humoral immunity and downregulate TH1 responses.
TOLEROGENIC DENDRITIC CELLS Dendritic cells that can attenuate T-cell-mediated immune responses by deleting, anergizing or changing the effector function of antigen-specific T cells.
VITILIGO A depigmenting disorder of the skin caused by the destruction of melanocytes that produce cutaneous pigments.
