Abstract

For a T-cell subset to be classified as immunoregulatory, it might reasonably be predicted that in its absence, animals would experience pathological immune dysregulation. Moreover, reconstitution of the subset should restore normal immune regulation. So far, these criteria have been satisfied by only a few of the candidate regulatory T-cell subsets, but among them is the intraepithelial T-cell receptor (TCR)⁺ subset of mouse skin. In this article, we look at immunoregulatory T cells, and the growing evidence for tissue-associated immunoregulation mediated by both T cells and T cells.

Author affiliations

1. Peter Gorer Department of Immunobiology, Guy's, King's and StThomas' Medical School, King's College, London SE1 9RT, UK.
2. Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06511, USA.

Correspondence to: Adrian Hayday¹ Email: adrian.hayday@kcl.ac.uk