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Perspective
Nature Reviews Immunology 3, 994–1003 (1 December 2003) | doi:10.1038/nri1249
Taking our breath away: dendritic cells in the pathogenesis of asthma
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Abstract
Dendritic cells (DCs) are mainly known for their capacity to induce primary immune responses. Here, we propose that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T-cell-mediated diseases. In the case of asthma, airway DCs are essential for controlling T helper 2 (TH2)-dependent eosinophilic airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
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