Review
Nature Reviews Immunology 3, 931-939 (December 2003) | doi:10.1038/nri1254
Human CD8+ T-cell differentiation in response to viruses
René A. W. van Lier1 About the author, Ineke J. M. ten Berge2 & Laila E. Gamadia1,2
Abstract
CD8+ T cells are essential in the defence against viruses. Recently, peptide–HLA class I tetramers have been used to study immune responses to viruses in humans. This approach has indicated consecutive stages of human CD8+ T-cell development in acute viral infection and has illustrated the heterogeneity of CD8+ T cells that are specific for latent viruses. Here, we summarize these findings and discuss their significance for our understanding of antigen-induced CD8+ T-cell maturation in humans.
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Author affiliations
- Department of Experimental Immunology, Academic Medical Centre, P.O. Box 11600, 1100AZ Amsterdam, The Netherlands.
- Renal Transplant Unit and Division of Rheumatology and Clinical Immunology, Academic Medical Centre, P.O. Box 11600, 1100AZ Amsterdam, The Netherlands.
Correspondence to: René A. W. van Lier1 Email: r.vanlier@amc.uva.nl
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