Perspectives
Nature Reviews Immunology 3, 994-1003 (December 2003) | doi:10.1038/nri1249
Opinion: Taking our breath away: dendritic cells in the pathogenesis of asthma
Bart N. Lambrecht1 About the author & Hamida Hammad1
Abstract
Dendritic cells (DCs) are mainly known for their capacity to induce primary immune responses. Here, we propose that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T-cell-mediated diseases. In the case of asthma, airway DCs are essential for controlling T helper 2 (TH2)-dependent eosinophilic airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
Author affiliations
- Bart N. Lambrecht and Hamida Hammad are at the Department of Pulmonary Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
Correspondence to: Bart N. Lambrecht1 Email: b.lambrecht@erasmusmc.nl
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