Abstract

The ability of naive T cells to clonally expand and acquire effector functions depends on the strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory receptors — the most prominent of which is CD28. In this review, we discuss recent genetic, biochemical and biophysical data that indicate a modified view of the molecular mechanism by which ligation of CD28 amplifies TCR-mediated T-cell activation. These studies indicate that the commonly held notion of a qualitative signalling role of CD28 in T-cell activation should be revised.

Author affiliations

1. Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 Rue du Dr Roux, Cedex 15, 75724 Paris, France.

Correspondence to: Oreste Acuto¹ Email: oacuto@pasteur.fr