Review
Nature Reviews Immunology 3, 939-951 (December 2003) | doi:10.1038/nri1248
CD28-mediated co-stimulation: a quantitative support for TCR signalling
Oreste Acuto1 & Frédérique Michel1 About the authors
Abstract
The ability of naive T cells to clonally expand and acquire effector functions depends on the strength of signals received by the T-cell receptor (TCR) and by an array of co-stimulatory receptors — the most prominent of which is CD28. In this review, we discuss recent genetic, biochemical and biophysical data that indicate a modified view of the molecular mechanism by which ligation of CD28 amplifies TCR-mediated T-cell activation. These studies indicate that the commonly held notion of a qualitative signalling role of CD28 in T-cell activation should be revised.
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Author affiliations
- Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25 Rue du Dr Roux, Cedex 15, 75724 Paris, France.
Correspondence to: Oreste Acuto1 Email: oacuto@pasteur.fr
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