Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Review
Nature Reviews Immunology 3, 900–911 (1 November 2003) | doi:10.1038/nri1226
Regulation of JAK|[ndash]|STAT signalling in the immune system
&
Abstract
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. Dysregulation of JAK–STAT signalling is associated with various immune disorders. The signalling strength, kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT pathway that will enhance our ability to design rational therapeutic strategies for immune diseases.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
