Nature Reviews Immunology 3, 900-911 (November 2003) | doi:10.1038/nri1226

Regulation of JAK–STAT signalling in the immune system

Ke Shuai1,2 & Bin Liu1  About the authors


The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. Dysregulation of JAK–STAT signalling is associated with various immune disorders. The signalling strength, kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT pathway that will enhance our ability to design rational therapeutic strategies for immune diseases.

Author affiliations

  1. Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA.
  2. Department of Biological Chemistry, University of California, Los Angeles, California 90095, USA.

Correspondence to: Ke Shuai1,2 Email:

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