Perspectives
Nature Reviews Immunology 2, 283-291 (April 2002) | doi:10.1038/nri779
Opinion — vaccines: The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?
Andrew McMichael1 & Tomâs Hanke1 About the authors
Abstract
The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.
Author affiliations
- Andrew McMichael and Tomâs Hanke are at the MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Correspondence to: Andrew McMichael1 Email: andrew.mcmichael@ndm.ox.ac.uk
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