Review
Nature Reviews Immunology 2, 251-262 (April 2002) | doi:10.1038/nri778
Subject Category: Vaccines
Vaccines: Effector and memory T-cell differentiation: implications for vaccine development
Susan M. Kaech1, E. John Wherry1 About the authors & Rafi Ahmed1
Abstract
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programme of development and the factors that might influence its progression. Models of the pathways of effector and memory T-cell differentiation are discussed, and we highlight the implications of this new understanding for the optimization of vaccine strategies.
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Author affiliations
- Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA.
Correspondence to: Rafi Ahmed1 Email: ra@microbio.emory.edu
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